FORMULATION AND IN -VITR0 EVALUATION OF NSAID’s GEL

The aim of this study was to improve the transdermal permeation of Diclofenac Soduim. Permeation studies were carried out in -vitro using Cellophane Membrane. Topical gel formulations of diclofenac sodium were prepared by using Carbopol 934, Carbopol 940, sodium carboxymethylcellulose (NaCMC), polymer as a gel-forming material that is biocompatible and biodegradable. The skin permeation enhancer on release characteristics of the diclofenac sodium from the prepared gels through a standard cellophane membrane was studied in comparison with commercially available gel formulations of diclofenac sodium. In-vitro Permeability study showed that permeation studies of Carbopol 934 and marketed gel were comparable. Tne in-vitro permeation studies by using cellophane membrane in Diffusion cell revealed good improvement of permeation characteristics of diclofenac sodium using Carbopol 940 gels as compared to the commercial gels. The permeation study enhancers such as isopropyl alcohol (IPA), Polyethylene glycol exhibited little or no effect on the permeation characteristics of diclofenac sodium. The samples withdrawn were spectrophotometrically estimated at 256nm against their respective blank. These types of topical dosage forms could give sustained delivery of drug onto the skin, so they are interesting promises to improve skin absorption of nonsteroidal anti-inflammatory drugs and to prevent side effects associated. The gel preparation is excellent in the percutaneous absorption of diclofenac or its salts and provides good properties upon use and superior medical effects of diclofenac or its salts.